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KMID : 1007520150240020717
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Food Science and Biotechnology
2015 Volume.24 No. 2 p.717 ~ p.723
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Antioxidative and Neuroprotective Effects of Volatile Components in Essential Oils from Chrysanthemum indicum Linne Flowers
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Lee Bong-Han
Nam Tea-Gyu
Park Woo-Jung
Kang Hee
Heo Ho-Jin
Chung Dae-Kyun
Kim Gun-Hee
Kim Dae-Ok
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Abstract
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Chrysanthemum indicum Linne, belonging to the family Compositae, is a perennial herb that is widespread in Korea. C. indicum Linne flowers have been traditionally used as an oriental medicine for treatment of infectious diseases. The chemical compositions, antioxidant capacity, and neuroprotective effects of volatile components in essential oils from C. indicum Linne flowers were investigated. GCMS analysis of essential oils revealed the 15 major components of 1,8-cineole, o-cymene, camphor, pinocarvone, chrysanthenyl acetate, bornyl acetate, trans-caryophyllene, terpinen-4-ol, umbellulone, trans-pinocarveol, cis-verbenol, borneol, α-terpineol, caryophyllene oxide, and thymol. Thymol had the highest antioxidant capacity. Essential oils and thymol dose-dependently decreased intracellular oxidative stress, exhibited anticholinesterase activities, and increased the cell viability of neuronal PC-12 cells. Essential oils and thymol from C. indicum Linne flowers can be sources of natural antioxidants and functional foods.
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KEYWORD
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anticholinesterase activity, GC-MS, oxidative stress, thymol, vitamin C equivalent antioxidant capacity
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